effect of induced hyperprolactinemia and its suppression by bromocriptine on some metabolic and hormonal patterns in adult female rats

Hyperprolactinemia was induced in 42 normal cycling adult female rats by daily S/C injection of estradiol benzoate for 10 days. Two dose levels of bromocriptine/animal as antiprolactin were daily S/C injected for 7 and 15 days. The effect of the induced hyperprolactinemia and its suppression on serum levels of estradiol-17 beta, progesterone, insulin, cortisol, glucose, albumin, triglycerides, cholesterol and calcium in adult female rats was studied. Hyperprolactinemia was accompanied by an elevation of serum estradiol-17 beta, insulin, cortisol, glucose, albumin, triglycerides, cholesterol and calcium; while, progesterone levels was declined significantly. Meanwhile, serum urea showed insignificant changes. On the other h and, treatment with bromocriptine decreased serum levels of estradiol-17 beta, glucose, triglycerides and cholesterol; while insulin and albumin levels were still significantly higher in female rats treated with bromocriptine [10 mug]. Serum calcium was significantly higher at 7 days in female rats treated with 10 or 20 mug bromocriptine, then declined after 15 days of treatment. Serum cortisol level of female rats treated by estradiol benzoate was not affected by bromocriptine treatment and still elevated. It can be concluded that hyperprolactinemia induced by estradiol benzoate resulted in metabolic and hormonal changes which could be normalized by bromocriptine treatment

Influence of pituitary extract injection on some metabolic parameters in catfish clarias lazera

In fish, pituitary hormones have been implicated in the regulation of metabolism beside their effects on gonadal activities. Male and female catfish Clarias lazera were injected with catfish pituitary extract. Samples were taken after two, four and six days of treatment. Serum alkaline phosphatase increased as a result of treatment, while serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT] decreased than control fish. The results of total protein and urea revealed a significant decline; while albumin, albumin globulin ratio and creatinine were not affected by treatment